Bioorthogonal chemistry for prodrug activation in vivo

文献情報

出版日 2023-10-31

DOI 10.1039/D2CS00889K

インパクトファクター 54.564

著者

Siyong Shen, Pengwei Sun, Zhi Gu, Yifei Bai, Xianglin Wang

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要旨

Prodrugs have emerged as a major strategy for addressing clinical challenges by improving drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence of new bioorthogonal chemistry has greatly facilitated the development of prodrug strategies, enabling their activation through chemical and physical stimuli. This “on-demand” activation using bioorthogonal chemistry has revolutionized the research and development of prodrugs. Consequently, prodrug activation has garnered significant attention and emerged as an exciting field of translational research. This review summarizes the latest advancements in prodrug activation by utilizing bioorthogonal chemistry and mainly focuses on the activation of small-molecule prodrugs and antibody–drug conjugates. In addition, this review also discusses the opportunities and challenges of translating these advancements into clinical practice.

掲載誌

Chemical Society Reviews

CiteScore: 80.8

自己引用率: 1.2%

年間論文数: 250

Chem Soc Rev publishes review articles covering important topics at the forefront of the chemical sciences. Reviews should be of the very highest quality and international impact. We particularly encourage international and multidisciplinary collaborations among our authors. Our scope covers the breadth of the chemical sciences, including interdisciplinary topics where the article has a basis in chemistry. Topics include: Analytical chemistry Biomaterials chemistry Bioorganic/medicinal chemistry Catalysis Chemical Biology Coordination Chemistry Crystal Engineering Energy Sustainable chemistry Green chemistry Inorganic chemistry Inorganic materials Main group chemistry Nanoscience Organic chemistry Organic materials Organometallics Physical chemistry Supramolecular chemistry Synthetic methodology Theoretical and computational chemistry

Bioorthogonal chemistry for prodrug activation in vivo

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