Ruthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones

文献情報

出版日 2021-12-03

DOI 10.1039/D1QO01598B

インパクトファクター 5.281

著者

Chenghao Li, Shuxin Zhang, Shan Li, Yu Feng, Qing-Hua Fan

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要旨

An efficient Ru-catalyzed enantioselective hydrogenation of quinoxalinone and quinazolinone derivatives has been successfully developed, providing a straightforward and facile access to chiral dihydroquinoxalinones and dihydroquinazolinones with excellent results (89–98% yields, up to 98% ee). Importantly, the key enantiopure dihydroquinoxalinone intermediate towards the synthesis of a bioactive BRD4 inhibitor was conveniently synthesized by this catalytic hydrogenation methodology.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Ruthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones

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