Ligand-accelerated site-selective Csp2–H and Csp3–H alkynylations of alcohols via Pd(ii) catalysis

文献情報

出版日 2021-10-02

DOI 10.1039/D1QO01095F

インパクトファクター 5.281

著者

Aidong Huang, Yishen Han, Peiqing Wu, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li

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要旨

A ligand-accelerated site-selective C–H alkynylation of weakly coordinated yet synthetically promising alcohols, via putative 6, 7 and 8-membered palladacycle intermediates, was developed. The endo-type C–H activation of olefins has been previously well developed, and in the current work we developed an exo C–H alkynylation of alkenols. Importantly, by making judicious choices of amide attached oximes, challenging secondary and tertiary Csp3–H alkynylations of alcohols were also realized.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Ligand-accelerated site-selective Csp2–H and Csp3–H alkynylations of alcohols via Pd(ii) catalysis

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