Zinc–Brønsted acid mediated practical hydrotrifluoromethylation of alkenes with CF3Br

文献情報

出版日 2021-09-13

DOI 10.1039/D1QO01073E

インパクトファクター 5.281

著者

Deqian Peng, Wu Fan, Xueqi Zhao, Wei Chen, Yuan Wen, Li Zhang

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要旨

We report a mild and efficient hydrotrifluoromethylation of alkenes with bromotrifluoromethane (CF3Br) mediated by zinc and a Brønsted acid. This reaction proceeds well with good functional group compatibility and broad substrate scope. Mechanistic studies indicate that the reaction proceeds through a radical pathway, facilitated through the combination of the zinc metal and a Brønsted acid for the single electron reduction of CF3Br to the CF3 radical. Furthermore, the method readily allows the incorporation of deuterium using deuterated carboxylic acid and D2O.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Zinc–Brønsted acid mediated practical hydrotrifluoromethylation of alkenes with CF3Br

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