One pot synthesis of isocyano-containing, densely functionalised gem-difluoroalkenes from α-trifluoromethyl alkenes, alkyl halides and TosMIC

文献情報

出版日 2021-08-26

DOI 10.1039/D1QO01024G

インパクトファクター 5.281

著者

Hongtai Huang, Junyu Chen, Yubo Jiang, Tiebo Xiao

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要旨

Here we report a base-promoted one-pot, three-component reaction of TosMIC with α-trifluoromethyl alkenes and alkyl halides for the synthesis of isocyano- containing, densely functionalised gem-difluoroalkenes. This protocol displays broad scope and excellent functional group compatibility. Moreover, we demonstrate that the products can be used as precursors to various medicinally relevant fluorine- or heterocycle-containing compouds.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

One pot synthesis of isocyano-containing, densely functionalised gem-difluoroalkenes from α-trifluoromethyl alkenes, alkyl halides and TosMIC

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