Asymmetric total synthesis and antidepressant activity of (−)-sila-mesembranol bearing a silicon stereocenter

文献情報

出版日 2021-08-23

DOI 10.1039/D1QO00682G

インパクトファクター 5.281

著者

Gan Luo, Lingmin Chen, Yi Li, Yu Fan, Duyang Wang, Yufan Yang, Lu Gao, Ruotian Jiang, Zhenlei Song

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要旨

Asymmetric total synthesis of (−)-sila-mesembranol, the silicon analog of the natural alkaloid (−)-mesembranol has been achieved in 3.3% yield over 11 steps. The chiral silicon center was enantioselectively constructed via the asymmetric expansion of a silacyclobutane ring. The synthetic (−)-sila-mesembranol in mice exhibits better antidepressant effects than its carbon counterpart.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Asymmetric total synthesis and antidepressant activity of (−)-sila-mesembranol bearing a silicon stereocenter

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