A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging

文献情報

出版日 2021-04-26

DOI 10.1039/D1QO00350J

インパクトファクター 5.281

著者

Xiaoyun Ran, Qian Zhou, Jin Zhang, Shanqiang Wang, Gui Wang, Hui Yang, Xiaochun Liu, Zhouyu Wang

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要旨

Starting from citric acid (CA) and ethylenediamine derivatives, a solvent-free, catalyst-free and high yielding synthesis approach for bicyclic 2-pyridones is presented. By continuously modifying the core structure, a series of novel and bright fluorophores with outstanding endoplasmic reticulum targeting properties (Pearson's coefficients = 0.89–0.97) and antibacterial activities were obtained. Theoretical calculations and single-crystal structures were further investigated to help reveal the structure–activity relationship. The green preparation method and excellent biological properties make these bicyclic 2-pyridone derivatives very promising for future applications.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging

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