Polymer based nanoparticles for biomedical applications by microfluidic techniques: from design to biological evaluation

文献情報

出版日 2021-10-19

DOI 10.1039/D1PY01077H

インパクトファクター 5.582

著者

Antonio Fabozzi, Francesca Della Sala, Mario di Gennaro, Nicola Solimando, Maurizio Pagliuca, Assunta Borzacchiello

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要旨

The development of microfluidic technologies represents a new strategy to produce and test drug delivery systems. In particular, microfluidics can facilitate the development of new nanoparticle-based systems with controlled physicochemical properties and evaluate their efficiency and efficacy in in vitro biomimetic models of human organs (organ-on-a-chip). Microfluidics shows promising effective potential for the preclinical testing of nanoparticle-based drug delivery systems compared to the traditional in vitro cell culture. In this review, we present a detailed state-of-the-art based on the microfluidic technologies focusing on the synthesis, industrial scale-up, and biological characterization of polymeric nanoparticles for drug delivery applications.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Polymer based nanoparticles for biomedical applications by microfluidic techniques: from design to biological evaluation

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