Synthesis and sequencing of informational poly(amino phosphodiester)s

文献情報

出版日 2021-09-13

DOI 10.1039/D1PY01052B

インパクトファクター 5.582

著者

Ian Roszak, Laurence Oswald, Abdelaziz Al Ouahabi, Eline Laurent, Olivier Felix, Isaure Carvin-Sergent, Laurence Charles, Jean-François Lutz

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要旨

Sequence-defined poly(amino phosphodiester)s containing main-chain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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Synthesis and sequencing of informational poly(amino phosphodiester)s

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