Electron attachment to isolated and microhydrated favipiravir
文献情報
Thomas F. M. Luxford, Jaroslav Kočišek
Electron attachment and its equivalent in complex environments, single-electron reduction, are important in many biological processes. Here, we experimentally study the electron attachment to favipiravir, a well-known antiviral agent. Electron attachment spectroscopy is used to explore the energetics of associative (AEA) and dissociative (DEA) electron attachment to isolated favipiravir. AEA dominates the interaction and the yields of the fragment anions after DEA are an order of magnitude lower than that of the parent anion. DEA primary proceeds via decomposition of the CONH2 functional group, which is supported by reaction threshold calculations using ab initio methods. Mass spectrometry of small favipiravir–water clusters demonstrates that a lot of energy is transferred to the solvent upon electron attachment. The energy gained upon electron attachment, and the high stability of the parent anion were previously suggested as important properties for the action of several electron-affinic radiosensitizers. If any of these mechanisms cause synergism in chemo-radiation therapy, favipiravir could be repurposed as a radiosensitizer.
関連文献
Gas-phase aluminium acetylacetonate decomposition: revision of the current mechanism by VUV synchrotron radiation
Patrick Hemberger, Andras Bodi
DOI: 10.1039/D1CP00720C
Heme is responsible for enhanced singlet oxygen deactivation in cytochrome c
Andrej Hovan, Martin Berta, Dagmar Sedláková, Gregor Bánó, Erik Sedlák
DOI: 10.1039/D1CP01517F
In situ illumination with inelastic neutron scattering: a study of the photochromic material cis-1,2-dicyano-1,2-bis(2,4,5-trimethyl-3-thienyl)ethene (CMTE)
Hamish Cavaye, Maksim Schastny
DOI: 10.1039/D1CP03716A
Enhancing the yield of calcium carbonate precipitation by obstacles in laminar flow in a confined geometry
Katalin Viktória Bere, Emilie Nez, Edina Balog, László Janovák, Dániel Sebők, Ákos Kukovecz, Clément Roux, Veronique Pimienta, Gábor Schuszter
DOI: 10.1039/D1CP01334C
Ultra-wideband and wide-angle perfect solar energy absorber based on Ti nanorings surface plasmon resonance
Fengqi Zhou, Feng Qin, Weitang Yao, Zhimin Liu, Xianwen Wu, Pinghui Wu
DOI: 10.1039/D1CP03036A
Electronic spectra of ytterbium fluoride from relativistic electronic structure calculations
Kenneth G. Dyall, Lucas Visscher, André Severo Pereira Gomes
DOI: 10.1039/D1CP03701C
Strong response of Pt clusters to the environment and conditions, formation of metastable states, and simple methods to trace the reversible changes
Alexander S. Lisitsyn, Anastasiya S. Kadtsyna
DOI: 10.1039/D1CP01484F
Spectroscopic characterization and photochemistry of the vinylsulfinyl radical
Zhuang Wu, Lina Wang, Bo Lu, André K. Eckhardt, Peter R. Schreiner, Xiaoqing Zeng
DOI: 10.1039/D1CP02584H
Bicolour fluorescent molecular sensors for cations: design and experimental validation
DOI: 10.1039/D1CP01203G
Efficient solar photocatalytic hydrogen production using direct Z-scheme heterojunctions
Kejian Lu, Fangyong Hou, Wenlong Fu, Fei Xue
DOI: 10.1039/D1CP02356J
こちらもおすすめ
6-(三氟甲基)喹啉二甲酸とは何ですか?
6-(三氟甲基)喹啉二甲酸は、CAS番号849818-58-2の化合物です。これは6位に三氟甲基が置換された2-quinolinecarboxylic酸と呼ばれ...
tert-butyl 4-ヒドロキシ-4-メチルázepane-1-カーボキセイランを含む廃棄物はどのように処理すべきですか?
この化合物の廃棄物は、適切な容器で密封し、避光し、低温かつ乾燥した環境で保管してください。処理には専門の廃棄処理会社のサービスを活用するか、地元の環境保護法に従...
TIPAを取り扱う際の実験室安全事項は何ですか?
TIPAは揮発性が低く、毒性は低いですが、操作中の注意が必要です。PPE(個人防護具)を着用し、ドラフトチャンバー内で取り扱い、漏洩した場合は即座にSDS(安全...
3-甲硫基苯硼酸频呐酯とは何ですか?
3-甲硫基苯硼酸频呐酯は、CAS番号710348-63-3の化合物で、化学式はC14H19BO2Sです。これは2-[3-(メチルサルファニル)フェニル]-4,4...
N-[2-(二甲氨基)乙基]-N-甲基甲酰胺は安全ですか?
N-[2-(二甲氨基)乙基]-N-甲基甲酰胺は安全ではありません。吸入、皮膚接触、目接触は避けてください。稀な過剰反応やアレルギー反応がある可能性があります。適...
甲基丙烯酸甲瓦龙酸内酯とは何ですか?
CAS番号177080-66-9の化合物、4-メチル-2-オキトテトラヒドロ-2H-ピラノ-4-イルメタクリレートは、甲基丙烯酸の一種です。この化合物は透明な液...
2-メチルフェンチアルデヒドを取り扱う際の実験室安全事項は何ですか?
2-メチルフェンチアルデヒドは易燃物質であり、火気の使用や高温に注意が必要です。PPE(個人保護具)として、ゴーグルや手袋を使用し、ドラフトチャンバーを使用して...
2,4,6-三氯-5-氟嘧啶はどの業界で使用されていますか?
2,4,6-三氯-5-氟嘧啶は医薬品産業で広く使用されており、抗真菌薬や抗ウイルス薬の前駆体として機能します。また、高次元材料やセンサー技術の分野でも応用されて...
(S)-2-((叔丁氧基羰基)氨基)-3-(((2-苯基乙酰胺基)甲基)硫基)丙酸とは何ですか?
CAS番号57084-73-8の(S)-2-((叔丁氧基羰基)氨基)-3-(((2-苯基乙酰胺基)甲基)硫基)丙酸は、特定の構造を持つ無機化合物で、主に医薬品や...
掲載誌
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














