Recent advances in cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles

文献情報

出版日 2021-01-08

DOI 10.1039/D0QO01453B

インパクトファクター 5.281

著者

Jianhua Liao, Xiao Yang, Lu Ouyang, Yinlong Lai, Jiuzhong Huang, Renshi Luo

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要旨

Cascade radical cyclization is an attractive synthetic method due to its high atom- and step-economy to construct carbo- and heterocycles, which have wide applications in chemical and life science industries. Radical acceptors with unsaturated bonds play a key role in realizing highly rapid, concise, and efficient cascade radical cyclization. This Review is devoted to highlighting the latest achievements in the development of cascade radical cyclization methodologies for the synthesis of carbo- and heterocycles in this rapidly growing research field. Based on the hybridization of starting materials, this Review includes C(sp)–C(sp) bond, C(sp)–C(sp2) bond, C(sp2)–C(sp2) bond, C(sp2)–C(sp3), and carbon–heteroatom bond coupling cyclization. Representative examples mainly published in last three years will be discussed for each highlighted reaction design and mechanism, providing readers with common tools for future research in cascade radical cyclization.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry