Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines

文献情報

出版日 2020-12-30

DOI 10.1039/D0QO01416H

インパクトファクター 5.281

著者

Anan Wang, Xuesong Liu, Yi Kong, Jing Wang, Tao-Shan Jiang

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要旨

A metal-free direct synthesis of pyrimidines from amidine hydrochlorides, ketones and DMSO through substrate-induced DMSO activation and subsequent reactions has been developed. In this protocol, amidine hydrochlorides were not only used as reactants but also activated DMSO to form a sulfenium ion intermediate which then participated in the reactions.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines

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