Metallaphotoredox-catalyzed C–H activation: regio-selective annulation of allenes with benzamide‡

文献情報

出版日 2021-01-04

DOI 10.1039/D0QO01127D

インパクトファクター 5.281

著者

Zihao Zhu, Yuyuan Chen, Xueyao Li, Qingyun Yang, Jie Xia, Wenxuan Zhang, Chao Zhang, Song Wu

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要旨

We have developed an efficient annulation of benzamides with allenes using cobalt and photoredox dual catalysis under an oxygen atmosphere. This reaction provides a mild and environmentally friendly method for the construction of isoquinolinone scaffolds in good to excellent yields, demonstrating broad substrate scopes, high regioselectivity, and good functional group compatibility. Notably, the transformation features an alternative strategy for the regeneration of a cobalt catalyst with the aid of Eosin Y. Preliminary mechanistic studies reveal that a radical-mediated cascade annulation is involved in this reaction.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Metallaphotoredox-catalyzed C–H activation: regio-selective annulation of allenes with benzamide‡

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