Electrochemically promoted C-3 amination of 2H-indazoles

文献情報

出版日 2020-12-11

DOI 10.1039/D0QO01088J

インパクトファクター 5.281

著者

Yuhui Zhou, Laiqiang Li, Yongmin Ma, Pinhua Li

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要旨

This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Electrochemically promoted C-3 amination of 2H-indazoles

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