A one-pot three-component strategy for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives using recyclable solid acid as a catalyst

文献情報

出版日 2020-07-22

DOI 10.1039/D0QO00591F

インパクトファクター 5.281

著者

Furen Zhang, Chunmei Li, Chenze Qi

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要旨

An efficient and eco-friendly approach for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives has been developed. The one-pot three-component reaction enables multiple bond-forming events including C–C and C–N bonds under mild conditions using easily available starting materials, leading to diastereoselective generation of N-containing spirocycles. The advantages of inexpensive and easily available starting materials, green and mild reaction conditions, recyclable and easily separable heterogeneous catalysts, broad substrate scope and simple one-pot operation make this strategy highly attractive.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

A one-pot three-component strategy for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives using recyclable solid acid as a catalyst

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