Transition metal-catalyzed coupling of heterocyclic alkenes via C–H functionalization: recent trends and applications

文献情報

出版日 2020-04-29

DOI 10.1039/D0QO00279H

インパクトファクター 5.281

著者

Sundaravel Vivek Kumar, Sonbidya Banerjee, Tharmalingam Punniyamurthy

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要旨

Heterocyclic alkenes represent an important class of reactive feedstock and valuable synthons for the synthesis of biologically important heterocyclic scaffolds. Although functionalized heterocyclic alkenes and their derivatives can be accessed via metal-catalyzed cross-coupling reactions, yet the prefunctionalisation of starting materials makes the process a bit cumbersome. On the other hand, transition-metal-catalyzed C–H functionalization is one of the most persuasive and front-line research areas in modern synthetic organic chemistry for atom/step-economy, viability and high efficacy. This critical review highlights the recent advances in coupling of heterocyclic alkenes by transition-metal-catalyzed reactions with special emphasis on arylation, alkenylation, alkylation, hydroarylation, ring-opening addition and annulation/cyclization via the C–H functionalization strategy reported since 2015.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry