Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

文献情報

出版日 2020-04-16

DOI 10.1039/D0QO00259C

インパクトファクター 5.281

著者

Shuangshuang Xie, Changxing Qi, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun, Yuan Zhou, Yonghui Zhang

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要旨

Cyclooxygenase-2 (COX-2) is a significant therapeutic target of chronic inflammatory diseases. Soniiglucinols A–D (1–4), four new polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse architectures, were isolated from Hypericum wilsonii. Structurally, 1 and 2 represent the first examples of PPAPs that are uniquely defined by the presence of a fascinating tricyclo-[7.3.1.03,7]tridecane core bearing an unusual 5/7/6 carbon skeleton. Compounds 3 and 4 were the first PPAPs sharing intriguing tricyclo-[7.3.1.02,7]tridecane and tricyclo-[6.3.1.02,6]dodecane moieties, respectively. More significantly, 1 and 2 were the first reported PPAPs functioning as potent cyclooxygenase-2 (COX-2) inhibitors with efficient anti-inflammatory activities, which provided a basis to design novel COX-2 inhibitors based on the new tricyclo-[7.3.1.03,7]tridecane fragment.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

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