Development of a lateral flow test for rapid pyrethroid detection using antibody-gated indicator-releasing hybrid materials

文献情報

出版日 2020-04-06

DOI 10.1039/D0AN00319K

インパクトファクター 4.616

著者

Elena Costa, Estela Climent, Sandra Ast, Michael G. Weller, John Canning, Knut Rurack

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要旨

The employment of type-I pyrethroids for airplane disinfection in recent years underlines the necessity to develop sensing schemes for the rapid detection of these pesticides directly at the point-of-use. Antibody-gated indicator-releasing materials were thus developed and implemented with test strips for lateral-flow assay-based analysis employing a smartphone for readout. Besides a proper matching of pore sizes and gating macromolecules, the functionalization of both the material's outer surface as well as the strips with PEG chains enhanced system performance. This simple assay allowed for the detection of permethrin as a target molecule at concentrations down to the lower ppb level in less than 5 minutes.

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Development of a lateral flow test for rapid pyrethroid detection using antibody-gated indicator-releasing hybrid materials

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