Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441

文献情報

出版日 2020-01-09

DOI 10.1039/C9QO01365B

インパクトファクター 5.281

著者

Zhaoming Liu, Haibo Tan, Yuchan Chen, Saini Li, Haohua Li, Shuang Zhu, Hongxin Liu, Weimin Zhang

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要旨

Phomeroids A (1) and B (2), two novel meroterpenoids representing two types of skeletons, together with one known homologous analogue (3) were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Phomeroid A is the first example of tropolonic sesquiterpenes consisting of a highly fused 6/6/11/6/5/5 ring system, while phomeroid B is the first example of meroterpenoids featuring an unusual 7/6/11/6-5 spiral core skeleton. All of them showed considerable cytotoxicity against the tested cell lines, and their biosynthetic pathways were also discussed.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441

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