A metal-free aromatic cascade for the synthesis of diverse heterocycles

文献情報

出版日 2020-01-02

DOI 10.1039/C9QO01336A

インパクトファクター 5.281

著者

Steven C. Schlitzer, Dhanarajan Arunprasath, Katelyn G. Stevens, Indrajeet Sharma

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要旨

A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

A metal-free aromatic cascade for the synthesis of diverse heterocycles

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