Asymmetric total synthesis of nodulisporiviridin E

文献情報

出版日 2019-11-18

DOI 10.1039/C9QO01278H

インパクトファクター 5.281

著者

Yang Ji, Zhengyuan Xin, Yingbo Shi, Haibing He

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要旨

The asymmetric total synthesis of (+)-nodulisporiviridin E, a fungal metabolite from Nodulisporium sp., was achieved in 16 steps. The synthesis features a convergent approach from two conventional fragments. An intramolecular Heck cyclization was applied to construct the C-ring and the all-carbon quaternary center at C-10. The furan E ring was installed by means of an intramolecular oxonium trapping reaction. This approach provides an advanced Michael acceptor, which might facilitate the preparation of various analogues and derivatives for biological studies.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Asymmetric total synthesis of nodulisporiviridin E

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