Selective assembly of N1- and N2-alkylated 1,2,3-triazoles via copper-catalyzed decarboxylative cycloaddition of alkynyl carboxylic acids with ethers and azidotrimethylsilane

文献情報

出版日 2019-11-04

DOI 10.1039/C9QO01277J

インパクトファクター 5.281

著者

Pengli Bao, Na Meng, Yufen Lv, Huilan Yue, Jiang-Sheng Li

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要旨

A convenient and practical copper-catalyzed three component protocol has been developed for the selective assembly of N1- and N2-alkylated 1,2,3-triazoles from readily available alkynyl carboxylic acids, azidotrimethylsilane (TMSN3) and ethers. The present reaction can be achieved by decarboxylative cycloaddition of alkynyl carboxylic acids with TMSN3 and ethers, which is an efficient and selective approach to access a number of N1- and N2-alkylated 1,2,3-triazoles in moderate to good yields.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Selective assembly of N1- and N2-alkylated 1,2,3-triazoles via copper-catalyzed decarboxylative cycloaddition of alkynyl carboxylic acids with ethers and azidotrimethylsilane

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