N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis

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出版日 2019-10-21

DOI 10.1039/C9QO01074B

インパクトファクター 5.281

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要旨

N-Heterocyclic carbenes (NHCs) have emerged as efficient catalysts for promoting umpolung reactions of aldehydes and enals. To a certain extent, the NHC catalyzed umpolung reactions of Michael acceptors are also reported. Recently, the NHCs have been successfully used for catalysing the umpolung reactions of aldimines through the formation of aza-Breslow intermediates. The initial reports on the chiral NHC-catalysed enantioselective umpolung reactions of imines are turning out to be very promising to achieve a high level of enantio-induction. This highlight article focuses on the NHC catalysed umpolung reactions of aldimines, with a special emphasis on the corresponding enantioselective transformations.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis

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