Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

文献情報

出版日 2019-10-09

DOI 10.1039/C9QO01046G

インパクトファクター 5.281

著者

Da-Peng Qin, Qian-Qian Di, Ying Liu, Wei-Lin Chen, Shu-Mei Wang, Yong-Xian Cheng

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要旨

Commiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-κB and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

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