Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation

文献情報

出版日 2019-11-01

DOI 10.1039/C9QO01025D

インパクトファクター 5.281

著者

Muxing Zhou, Ende He, Lu Zhang, Jianzhong Chen, Zhenfeng Zhang, Yangang Liu

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要旨

A novel chiral nucleophilic organocatalyst easily synthesized from simple starting materials bearing a 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine skeleton has been developed and successfully applied in the direct enantioselective C-acylation of 3-substituted benzofuranones. Its catalytic efficiency was shown to be comparable to that of the previously reported chiral 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole catalyst. A wide range of 3,3-disubstituted benzofuranones, possessing a quaternary stereocenter, were synthesized with high yields and enantioselectivities.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation

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