Synthesis of paracyclophanes with planar and central chirality: kinetic resolution of [2.2]paracyclophane aldimines via palladium-catalyzed addition of arylboronic acids

文献情報

出版日 2019-10-28

DOI 10.1039/C9QO01011D

インパクトファクター 5.281

著者

Han Wang, Bo Wu

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要旨

Kinetic resolution of [2.2]paracyclophane aldimines was achieved through palladium-catalyzed enantioselective arylation with arylboronic acids. The catalytic process provided reliable access to enantiopure paracyclophane derivatives with planar and central chirality as well as the recovered chiral aldimines with a selectivity factor up to 368. Furthermore, the synthetic utility of the [2.2]paracyclophane aldimines has been demonstrated by converting them into useful chiral building blocks.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis of paracyclophanes with planar and central chirality: kinetic resolution of [2.2]paracyclophane aldimines via palladium-catalyzed addition of arylboronic acids

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