Synthesis of chromans and kinetic resolution of 2-aryl-3-nitro-2H-chromenes via the NHC-bound azolium homoenolate pathway

文献情報

出版日 2019-08-15

DOI 10.1039/C9QO00868C

インパクトファクター 5.281

著者

Aditya Bhattacharya, Pushpendra mani Shukla, Lalit Kumar Kaushik, Biswajit Maji

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要旨

Beyond the tandem oxa-Michael strategy, an N-heterocyclic carbene-catalyzed kinetic resolution approach to access highly diastereo- and enantioenriched 2-aryl-3-nitro-chromane derivatives has been developed. An efficient strategy for the kinetic resolution of racemic 2-aryl-3-nitro-2H-chromenes was also successfully achieved. This catalytic kinetic resolution method allows the synthetically valuable chiral scaffolds, chromane and 2H-chromene, to be accessed in a single catalytic and asymmetric transformation, through the NHC-bound azolium homoenolate pathway.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis of chromans and kinetic resolution of 2-aryl-3-nitro-2H-chromenes via the NHC-bound azolium homoenolate pathway

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