Rhodium(iii)-catalyzed ortho-C–H amidation of 2-arylindazoles with a dioxazolone as an amidating reagent

文献情報

出版日 2020-01-27

DOI 10.1039/C9OB02756D

インパクトファクター 3.876

著者

Payel Ghosh, Sadhanendu Samanta, Alakananda Hajra

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要旨

A simple and efficient method for the directed amidation of a wide range of 2-arylindazoles has been established for the first time through a rhodium-catalyzed C–H activation reaction with alkyl, aryl and heteroaryl dioxazolones. A series of N-(2-(2H-indazol-2-yl)phenyl)acetamide derivatives were synthesized in excellent yields. A mechanistic study was conducted to describe C–H bond cleavage which is likely to be involved in the rate determining step.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Rhodium(iii)-catalyzed ortho-C–H amidation of 2-arylindazoles with a dioxazolone as an amidating reagent

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