Micromachined multigroove silicon ATR FT-IR internal reflection elements for chemical imaging of microfluidic devices

文献情報

出版日 2019-10-24

DOI 10.1039/C9AY02248A

インパクトファクター 2.896

著者

Stuart T. Read, Garth Wells, Michael Jacobs, Scott M. Rosendahl, Sven Achenbach, Ian J. Burgess

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要旨

The performance of low-cost, microgroove silicon (Si)-based internal reflection elements (μ-groove IREs) for infrared chemical imaging of microfluidic devices is described. A custom-designed, horizontal microscope coupled with an imaging focal plane array area detector is described. After characterizing the inherent distortions of the microscope under wide field illumination, a checkerboard pattern lithographically printed on the principal reflection surface was imaged to determine the spatial resolution of the experimental setup which was approximately 14 μm per pixel. The image contains different regions of varying quality. Geometric ray tracing indicates that the different components in the image are caused by multiple beam paths through the μ-groove IRE. Regions of high image quality can be selected to cover a field of view with lateral dimensions of several hundred micrometers. Proof of concept chemical imaging with μ-groove IREs is demonstrated through the successful mapping of isotope exchange between two co-laminar flows of water and heavy water in a single microfluidic channel. A prospective on how imaging quality with near diffraction limited spatial resolution could be achieved is also provided.

掲載誌

Analytical Methods

CiteScore: 5.1

自己引用率: 3.7%

年間論文数: 655

Analytical Methods welcomes early applications of new analytical and bioanalytical methods and technology demonstrating the potential for societal impact. We require that methods and technology reported in the journal are sufficiently innovative, robust, accurate, and compared to other available methods for the intended application. Developments with interdisciplinary approaches are particularly welcome. Systems should be proven with suitably complex and analytically challenging samples. We encourage developments within, but not limited to, the following technologies and applications: global health, point-of-care and molecular diagnostics biosensors and bioengineering drug development and pharmaceutical analysis applied microfluidics and nanotechnology omics studies, such as proteomics, metabolomics or glycomics environmental, agricultural and food science neuroscience biochemical and clinical analysis forensic analysis industrial process and method development