A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

文献情報

出版日 2019-10-03

DOI 10.1039/C9AY01466G

インパクトファクター 2.896

著者

Duo Lin, Jiahui Zhou, Yun Yu, Weiwei Chen, Pei-Hsuan Liao, Hao Huang, Kien Voon Kong

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要旨

A fast SERS and colorimetric dual-modal assay for thiol detection was developed using an unsaturated triosmium carbonyl cluster, Os3(CO)10(μ-H)2, as a detection probe. The cluster undergoes a distinct color change in the presence of thiol and the SERS spectrum shows a shift in the CO stretching vibration, located in a silent region where there is no interference from biomolecules. Such assay offers high sensitivity with a detection limit up to 0.1 μM by SERS.

掲載誌

Analytical Methods

CiteScore: 5.1

自己引用率: 3.7%

年間論文数: 655

Analytical Methods welcomes early applications of new analytical and bioanalytical methods and technology demonstrating the potential for societal impact. We require that methods and technology reported in the journal are sufficiently innovative, robust, accurate, and compared to other available methods for the intended application. Developments with interdisciplinary approaches are particularly welcome. Systems should be proven with suitably complex and analytically challenging samples. We encourage developments within, but not limited to, the following technologies and applications: global health, point-of-care and molecular diagnostics biosensors and bioengineering drug development and pharmaceutical analysis applied microfluidics and nanotechnology omics studies, such as proteomics, metabolomics or glycomics environmental, agricultural and food science neuroscience biochemical and clinical analysis forensic analysis industrial process and method development