A tough and self-healing poly(l-glutamic acid)-based composite hydrogel for tissue engineering

文献情報

出版日 2018-09-27

DOI 10.1039/C8TB01981A

インパクトファクター 6.331

著者

Weijun Zhang, Kunxi Zhang, Shifeng Yan, Jie Wu, Jingbo Yin

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要旨

A hydrogel with excellent mechanical properties and self-healing ability provides a promising tool for the repair of load-bearing tissues under a dynamic microenvironment. In this study, poly(L-glutamic acid) (PLGA)-based composite hydrogels with good toughness and self-healing ability were fabricated via filling soft self-healing hydrogels into a tough porous hydrogel skeleton. The PLGA-based tough porous hydrogel skeleton was treated by laser ablation to form a uniform porous structure with 85% porosity and 260 μm pore diameter, and the structure formation was reinforced by the hydrophobic assembly mechanism. The resulting hydrogel skeleton possessed good toughness (maximum compressive stress of 0.51 MPa with strain of 80%) and could fully recover after cyclic compression tests. Furthermore, PLGA-based self-healing hydrogels were fabricated based on a Schiff base reaction, followed by being composited with a tough porous hydrogel skeleton. More importantly, the composite hydrogel exhibited a homogenous interpenetrated structure that inherited mechanical strength and the self-healing ability of the two original compositions. These composite hydrogels exhibited a compressive failure stress of 0.21 MPa at a 63% strain, which was 1.3-fold higher than the value of the original porous hydrogel skeleton at 63% strain. The healing percentage gradually reached 81% within 6 h, indicating the good self-healing efficiency. Furthermore, live/dead staining images revealed that 89% of laden cells remained alive after culture for 7 days. Moreover, the composite hydrogel could self-heal even after cell encapsulation. The developed PLGA-based composite hydrogel will be a promising biomaterial for the repair of load-bearing tissues.

掲載誌

Journal of Materials Chemistry B

CiteScore: 12

自己引用率: 4.9%

年間論文数: 831

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

A tough and self-healing poly(l-glutamic acid)-based composite hydrogel for tissue engineering

文献情報

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Journal of Materials Chemistry B

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