Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions

文献情報

出版日 2019-01-29

DOI 10.1039/C8RE00323H

インパクトファクター 4.239

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要旨

Herein, we describe a continuous flow protocol for the generation, purification and quantification of nitrosyl chloride (NOCl). The generation of this useful but hazardous reagent is based on the reaction of aqueous NaNO2 with HCl as readily available starting materials. The reagent, which is formed immediately upon mixing of the reactants, is rapidly extracted into a suitable organic phase, such as CHCl3 or CH2Cl2, and separated using a continuous flow liquid–liquid membrane separator. A convenient method for the in-line monitoring of reagent concentration, based on flow UV/vis analysis, has also been developed and implemented. The synthetic utility of the nitrosyl chloride generator was demonstrated by integrating a continuous flow photochemical reactor downstream to perform the synthesis of cyclohexanone oxime from cyclohexane, an important industrial process.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions

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Reaction Chemistry & Engineering

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