Iron-catalyzed reductive cyclization reaction of 1,6-enynes for the synthesis of 3-acylbenzofurans and thiophenes

文献情報

出版日 2018-12-14

DOI 10.1039/C8QO01190G

インパクトファクター 5.281

著者

Xiao-Feng Xia, Wei He, Guo-Wei Zhang, Dawei Wang

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要旨

A facile synthesis of 3-acylbenzofurans and thiophenes via iron(II)-catalyzed reductive cyclization of 1,6-enynes has been developed. A sequence involving hydrogen atom transfer (HAT)/cyclization and oxygen insertion has been proposed and confirmed by isotope experiments. This benign strategy provides a viable synthetic approach to valuable carbonylated heteroaromatic compounds using ethanol as the solvent and dioxygen as the oxidant.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Iron-catalyzed reductive cyclization reaction of 1,6-enynes for the synthesis of 3-acylbenzofurans and thiophenes

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