Copper-catalyzed [3 + 2] annulation of ethynyl epoxides with malononitrile to access highly substituted dihydrofurans with an all-carbon quaternary stereocenter

文献情報

出版日 2018-12-05

DOI 10.1039/C8QO01168K

インパクトファクター 5.281

著者

Xuanyi Li, Chunhua Han, Yue Huang, Hequan Yao, Aijun Lin

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要旨

An unprecedented copper-catalyzed [3 + 2] annulation with ethynyl epoxides and malononitrile has been described. This reaction provided a direct approach to the access of highly substituted dihydrofurans with an all-carbon quaternary stereocenter bearing a terminal alkynyl group in moderate to good yields, exhibiting excellent atom economy and scalability. The products enabled facile transformations into pyrimidinone and dihydrofuran-fused triazole derivatives.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-catalyzed [3 + 2] annulation of ethynyl epoxides with malononitrile to access highly substituted dihydrofurans with an all-carbon quaternary stereocenter

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