Regioselective indole C2-alkylation using β-CF3-substituted enones under redox neutral Rh(iii) catalysis

文献情報

出版日 2018-09-27

DOI 10.1039/C8QO00932E

インパクトファクター 5.281

著者

Bharatkumar Chaudhary, Monika Diwaker, Satyasheel Sharma

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要旨

Rhodium(III) catalyzed C–H alkylation at the C2-position of indole with β-trifluoromethyl-α,β-unsaturated ketones is described. The reactions proceed efficiently with low catalyst loading and a broad range of substrates with excellent functional group compatibility. The scale-up reaction was successfully achieved with 0.5 mol% of the Rh catalyst without significant decrease in the yield. This protocol provides direct access to pharmaceutically important indole derivatives containing a stereogenic carbon center bearing a CF3 functionality at the C2-position.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Regioselective indole C2-alkylation using β-CF3-substituted enones under redox neutral Rh(iii) catalysis

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