Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform‡

文献情報

出版日 2018-09-19

DOI 10.1039/C8QO00838H

インパクトファクター 5.281

著者

Jiajing Tan, Binbin Liu, Shuaisong Su

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要旨

The direct dearomatization reaction of isoquinolines and quinolines with chloroform has been accomplished through in situ electrophilic aryne activation and nucleophile formation. This transition metal-free protocol shows a broad scope of substrates, providing consistently high yields of medicinally-important dihydro(iso)quinoline derivatives. The utility of this method has been further demonstrated in the synthesis of deuterated analogues.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform‡

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