Rhodium(iii)/amine synergistically catalyzed enantioselective Michael addition of cyclic ketones with α,β-unsaturated 2-acyl imidazoles

文献情報

出版日 2018-09-03

DOI 10.1039/C8QO00809D

インパクトファクター 5.281

著者

Yu Du, Qiang Kang

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要旨

An enantioselective Michael addition of α,β-unsaturated 2-acyl imidazoles with cyclic ketones catalyzed synergistically by a chiral-at-metal Rh(III) complex and a secondary amine has been developed, affording the corresponding adducts with up to 98% yield and 99% ee. The diastereomeric ratios are in the range from 2 : 1 to 10 : 1. In these reactions, the combination of a chiral-at-metal complex and a secondary amine catalyst activates an electrophile and nucleophile separately.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Rhodium(iii)/amine synergistically catalyzed enantioselective Michael addition of cyclic ketones with α,β-unsaturated 2-acyl imidazoles

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