Alkylation–peroxidation of α-carbonyl imines or ketones catalyzed by a copper salt via radical-mediated Csp3–H functionalization

文献情報

出版日 2018-09-18

DOI 10.1039/C8QO00797G

インパクトファクター 5.281

著者

Meng Lei, Yanjun Li, Shi Cao, Xinyi Hou, Lei Gong

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要旨

The catalytic alkylation–peroxidation of α-carbonyl imines or ketones was enabled by a simple copper salt under very mild reaction conditions. The transformations involved radical-mediated Csp3–H functionalization and afforded stable α-amino or α-alkyloxyl peroxides in good to excellent yields. This strategy would potentially provide a straightforward approach to direct difunctionalization of carbon−heteroatom double bonds and construction of structurally novel organic peroxides.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Alkylation–peroxidation of α-carbonyl imines or ketones catalyzed by a copper salt via radical-mediated Csp3–H functionalization

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