Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products

文献情報

出版日 2018-10-11

DOI 10.1039/C8QO00781K

インパクトファクター 5.281

著者

Xinyu Duan, Pengbin Li, Guirong Zhu, Chunling Fu, Qin Chen, Xin Huang

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要旨

With the readily available Gorlos-Phos as a ligand, unsymmetrical biaryls were prepared efficiently from Pd-catalyzed one-pot two-step cross-coupling of two different aryl chlorides in the presence of B2Pin2, tolerating functional groups such as aldehyde, ketone, ester, ether, nitrile, amide, fluorine, sulphonyl and trifluoromethyl groups. Besides the substituted phenyl chlorides, hetero-aryl chlorides, 1-chloronaphthalene, and dichlorobenzenes could also be applied. The cytotoxicity against human lung cancer A549 cells for some of the compounds has been studied.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products

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