Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones

文献情報

出版日 2018-08-08

DOI 10.1039/C8QO00565F

インパクトファクター 5.281

著者

Yi-Nan Lu, Chun Ma, Jin-Ping Lan, Caiqiang Zhu, Yu-Jia Mao, Guang-Jian Mei, Shu Zhang, Feng Shi

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要旨

2,3-Indolyldimethanols as a new class of indolyldimethanols have been designed, and the first catalytic asymmetric substitution of 2,3-indolyldimethanols has been established by using cyclic enaminones as nucleophiles, which afforded substitutive products in an enantioselective and regioselective mode (up to 98% ee, all >95 : 5 rr). This reaction represents the first design and application of 2,3-indolyldimethanols in catalytic asymmetric reactions, which will greatly enrich the chemistry of indolyldimethanols.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones

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