Logical design and application of prodrug platforms

文献情報

出版日 2018-11-12

DOI 10.1039/C8PY01160E

インパクトファクター 5.582

著者

Qingye Meng, Hao Hu, Liping Zhou, Yixin Zhang

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要旨

Accurate design and high drug-loading content are the two key points in designing high-performance cancer nanomedicines. Using common strategies for drug delivery systems (DDS), such as nanoparticle (NP)-mediated DDS, lipid nanocarrier-mediated DDS, and micelle-mediated DDS, it is difficult to meet the requirements for their translation into clinical applications because of the imprecise control of the conjugation sites and density. Using drug molecules to directly construct the delivery platform is a promising approach to precisely control the composition and molecular structure. The polyprodrug platform for disease treatment is an advanced strategy with a precise structure and a high drug-loading rate. This review summarizes the current state of prodrugs, especially the polyprodrug platform, and focuses on the logical design for clinical use and proposes some practical prospects for the future development of the prodrug platform.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Logical design and application of prodrug platforms

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