A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

文献情報

出版日 2018-12-12

DOI 10.1039/C8OB02970A

インパクトファクター 3.876

著者

Manickam Bakthadoss, Srinivasan Jayakumar, Selvakumar Raman, Anthonisamy Devaraj, Duddu S. Sharada

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要旨

A novel multicomponent quadruple domino reaction (MCQDR) for the assembly of structurally complex molecular architectures via the formation of three rings and three contiguous stereogenic centers has been accomplished with high regio- and diastereoselectivity. Solvents, catalysts and work-up were not required to obtain the target molecules. In addition, this new protocol is also extended for the multicomponent double quadruple domino reaction (MCDQDR) to create novel polyheterocyclic architectures in an orthogonal manner.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

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Organic & Biomolecular Chemistry

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