Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

文献情報

出版日 2018-11-27

DOI 10.1039/C8OB02665C

インパクトファクター 3.876

著者

Zeng-Fei Pei, Min-Jie Yang, Lei Li, Xiao-Hong Jian, Yue Yin, Dehai Li, Hai-Xue Pan, Yinhua Lu, Weihong Jiang, Gong-Li Tang

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要旨

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

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