A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles‡

文献情報

出版日 2018-07-24

DOI 10.1039/C8OB01471J

インパクトファクター 3.876

著者

Gabriella Ieronimo, Giovanni Palmisano, Angelo Maspero, Alessandro Marzorati, Luca Scapinello, Norberto Masciocchi, Giancarlo Cravotto, Alessandro Barge, Marco Simonetti, Keshav Lalit Ameta, Kenneth M. Nicholas, Andrea Penoni

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要旨

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles‡

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Organic & Biomolecular Chemistry

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