Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

文献情報

出版日 2018-03-07

DOI 10.1039/C8OB00329G

インパクトファクター 3.876

著者

Susan E. Hagen, Kun Liu, Yafei Jin, Lolita Piersimoni, Hollis D. Showalter

原文を見る

要旨

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts. Each exhibits high aqueous solubility, excellent protein crosslinking efficiencies, low collision induced dissociation (CID) energy fragmentation efficiencies, high stoichiometries of reaction, increased charges of crosslinked peptide ions, and maintenance of overall surface charge balance of crosslinked proteins.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

文献情報

おすすめジャーナル

関連文献

A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid‡

Unique intermolecular reaction of simple porphyrins at a metal surface gives covalent nanostructures

Angle-controlled arrangement of single-walled carbon nanotubes solubilised by 8-quinolinol metal chelate derivatives on mica

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

Recent progress in the immobilization of catalysts for selective oxidation in the liquid phase

Functionalized polyesters from organocatalyzed ROP of gluOCA, the O-carboxyanhydride derived from glutamic acid

Phase-transfer catalytic aza-Michael addition of tert-butyl benzyloxycarbamate to electron-deficient olefins

A new NCN pincer ruthenium complex and its catalytic activity for enantioselective hydrogenation of ketones

Rigid cyanine dyenucleic acid labels‡

Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin‡

こちらもおすすめ

3-イチチルビフェニルはどのように合成されますか？

8-溴-5-三氟甲基喹啉はどのように合成されますか？

ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか？

N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか？

イソステアロイルグリセリルは安全ですか？

1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか？

3-チオフェンスチオールの物理化学的性質は何ですか？

2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか？

CAS番号1316822-90-8の化合物は安全ですか？

Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

Fmoc-beta-(benzothiazol-2-yl)-L-alanine

(2R,6S)-6-[(Benzyloxy)methyl]-4-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-morpholinecarboxylic acid

N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-methionylglycine

2-Carboxymethyl-benzoic acid tert-butyl ester

2-(Pyrrolidin-2-yl)pyridine dihydrochloride

おすすめサプライヤー