A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

文献情報

出版日 2018-04-04

DOI 10.1039/C8OB00169C

インパクトファクター 3.876

著者

Dejun Ma, Changyu Zhang, Yuwen Men, Hongyan Sun, Lu-Yuan Li, Long Yi, Zhen Xi

原文を見る

要旨

A new bench-stable reagent with double diazonium sites was designed and synthesized for protein crosslinking. Based on the highly efficient diazonium-Tyr coupling reaction, a direct mixture of the reagent and tobacco mosaic virus led to the formation of a new hydrogel, which could be degraded by chemicals and could be used to encapsulate small molecules for sustained release. Because plant viruses exhibit many chemical characteristics like protein labelling and nucleic acid packaging, the virus-based hydrogel will have large chemical space for further functionalization. Besides, this dual-diazonium reagent should be a generally useful crosslinker for chemical biology and biomaterials.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

文献情報

おすすめジャーナル

関連文献

Nitrite and nitrate formation on model NOx storage materials: on the influence of particle size and composition

Film formation and surface gelation of gelatin molecules at the water/air interface

Probing the catalytic activity and heterogeneity of Au-nanoparticles at the single-molecule level

Unrestricted study of the Eley–Rideal formation of H2 on graphene using a new multidimensional graphene–H–H potential: role of the substrate

Au nanoparticles on a templating TiOx/Pt(111) ultrathin polar film: a photoemission and photoelectron diffraction study

Charge transfer in Cr adsorption and reaction at the rutile TiO2(110) surface

A coarse-graining procedure for polymer melts applied to 1,4-polybutadiene

Multireference state-specific coupled-cluster methods. State-of-the-art and perspectives

Molecular dynamics study of the effect of cholesterol on the properties of lipid monolayers at low surface tensions

Manipulation of the local density of photonic states to elucidate fluorescent protein emission rates

こちらもおすすめ

5-苄基四氢吡咯并[3,4-c]吡咯-1,3[2H,3ah]-二酮の主な用途は何ですか？

唾液酸路易ス Aを取り扱う際の実験室安全事項は何ですか？

タルトブチル ((1-(2-クロロアセチル)ピペリジン-4-イルメチル)カーバamatはどの業界で使用されていますか？

3-烯丙基-2-羟基苯甲醛の物理化学的性質は何ですか？

乳清酸 Potassium Orotateとは何ですか？

4-甲基苯磺酸异丙酯はどの業界で使用されていますか？

6-(3- Florobenzen)-N-[1-(2,2,2- Trifluoroethyl)-4-Piperidinyl]-3-Pyridinycarboxamideはどの業界で使用されていますか？

左西孟旦はどのように合成されますか？

3-乙氧基哌啶盐酸盐に適用される法規ガイドラインは何ですか？

Diethyl (hydroxymethyl)phosphonateの主な用途は何ですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(6-quinolinyl)acetamide

4,4-Diphenyl-2-cyclohexen-1-one

Yoshimulactone Green (YLG)

(2-Phenoxyphenyl)hydrazine hydrochloride (1:1)

2-Phenylanthracene

おすすめサプライヤー