Time-resolved IR spectroscopy reveals mechanistic details of ion transport in the sodium pump Krokinobacter eikastus rhodopsin 2
文献情報
Marvin Asido, Peter Eberhardt, Clara Nassrin Kriebel, Markus Braun, Clemens Glaubitz, Josef Wachtveitl
We report a comparative study on the structural dynamics of the light-driven sodium pump Krokinobacter eikastus rhodopsin 2 wild type under sodium and proton pumping conditions by means of time-resolved IR spectroscopy. The kinetics of KR2 under sodium pumping conditions exhibits a sequential character, whereas the kinetics of KR2 under proton pumping conditions involves several equilibrium states. The sodium translocation itself is characterized by major conformational changes of the protein backbone, such as distortions of the α-helices and probably of the ECL1 domain, indicated by distinct marker bands in the amide I region. Carbonyl stretch modes of specific amino acid residues helped to elucidate structural changes in the retinal Schiff base moiety, including the protonation and deprotonation of D116, which is crucial for a deeper understanding of the mechanistic features in the photocycle of KR2.
おすすめジャーナル

Contact Lens & Anterior Eye

Angewandte Chemie International Edition

Current Pharmaceutical Biotechnology

Faraday Discussions

Photochemical & Photobiological Sciences

Environmental Toxicology and Pharmacology

Physical Chemistry Chemical Physics

Journal of Enzyme inhibition and Medicinal Chemistry

Green Chemistry

Nature Reviews Drug Discovery
関連文献
Recent advances in the utilization of covalent organic frameworks (COFs) as electrode materials for supercapacitors
Shen Xu, Jinghang Wu, Xiang Wang
DOI: 10.1039/D3SC04571D
Thermally activated delayed fluorescence in a mechanically soft charge-transfer complex: role of the locally excited state
Kalyan Jyoti Kalita, Saikat Mondal, C. Malla Reddy, Ratheesh K. Vijayaraghavan
DOI: 10.1039/D3SC03267A
Thermally activated delayed fluorescence in a deep red dinuclear iridium(iii) complex: a hidden mechanism for short luminescence lifetimes
Andrey V. Zaytsev, Amit Sil, Glib V. Baryshnikov, J. A. Gareth Williams, Fernando B. Dias, Valery N. Kozhevnikov
DOI: 10.1039/D3SC04450E
Improving the potential of paraCEST through magnetic-coupling induced line sharpening
Xin Guo, Jiesheng Hu, Meng Yu, Gyula Tircsó, Jun Tao
DOI: 10.1039/D3SC04770A
Visible light-induced palladium–carbon bond weakening in catalytically relevant T-shaped complexes
Peter M. Waddell, Lei Tian, Anthony R. Scavuzzo, Lalu Venigalla, Gregory D. Scholes, Brad P. Carrow
DOI: 10.1039/D3SC02588H
Triplet dynamic nuclear polarization of pyruvate via supramolecular chemistry
Tomoyuki Hamachi, Koki Nishimura, Keita Sakamoto, Yusuke Kawashima, Hironori Kouno, Shunsuke Sato
DOI: 10.1039/D3SC04123A
(C5H6.16N2Cl0.84)(IO2Cl2): a birefringent crystal featuring unprecedented (IO2Cl2)− anions and π-conjugated organic cations
Chun-Li Hu
DOI: 10.1039/D3SC05770D
Selective chiral dimerization and folding driven by arene–perfluoroarene force
Qiuhong Cheng, Aiyou Hao, Pengyao Xing
DOI: 10.1039/D3SC05212E
Solution-state mechanochromic luminescence of Pt(ii)-complexes displayed within micellar aromatic capsules
Yoshihisa Hashimoto, Yuri Katagiri, Yuya Tanaka, Michito Yoshizawa
DOI: 10.1039/D3SC04613C
18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma
Jonathan E. Tsang, David A. Nathanson
DOI: 10.1039/D3SC04424F
こちらもおすすめ
2-ブロモ-9,9-ジフェニル-9H-フルオレンの主な用途は何ですか?
2-溴-9,9-二苯基芴は、医薬品、工業材料、有機合成の研究分野で応用されます。特に、レーザー材料や機能性ポリマーの合成に使用されることがあります。また、蛍光色...
四氯化铱の市場動向や研究トレンドはどうですか?
四氯化铱の市場は研究開発分野で注目されており、特にナノ技術や金属有機框架(MOFs)の分野での需要が増加傾向にあります。価格は安定しており、中国や韓国での生産が...
1-(4-溴-3-氟苯基)-2-氯乙酮を含む廃棄物はどのように処理すべきですか?
1-(4-溴-3-氟苯基)-2-氯乙酮 (CAS番号: 1260857-14-4) の廃棄物は専門的な廃棄処理が必要です。まず、廃棄物は密閉された容器に収集し、...
苦参酚Kとは何ですか?
苦参酚Kは、CAS番号101236-49-1を持つ化合物で、主に天然由来の生薬から抽出されます。この化合物は、抗炎症作用や抗癌作用を持つことが報告されています。
POTASSIUM (1-(TERTBUTOXYCARBONYL)AZETIDIN-3-YL)TRIFLUOROBORATE を含む廃棄物はどのように処理すべきですか?
POTASSIUM (1-(TERTBUTOXYCARBONYL)AZETIDIN-3-YL)TRIFLUOROBORATE を含む廃棄物は、まず安全なエント...
4-庚基-4’-联苯羧酸の市場動向や研究トレンドはどうですか?
4-庚基-4’-聯苯羧酸は、特殊化学品や合成化学の分野で用いられる化学物質ですが、市場動向としては、研究開発の進展とともに需要が増加しています。また、環境配慮型...
6-ブロモ-3-メトキシ-1-フェニル-1H-インドゾールを含む廃棄物はどのように処理すべきですか?
6-ブロモ-3-メトキシ-1-フェニル-1H-インドゾールを含む廃棄物は、適切な化学廃棄処理が必要です。通常、廃棄物は密閉容器に収集され、専門の廃棄処理業者に引...
4,4-二甲基-2-吡咯烷酮はどの業界で使用されていますか?
4,4-二甲基-2-吡咯烷酮は医薬、ポリマー、センサー、半導体などの業界で広く使用されています。特に溶媒としての性能が高く評価されています。
掲載誌
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.
![Pyrazolo[1,5-a]pyridine-3-carbothioamide structure Pyrazolo[1,5-a]pyridine-3-carbothioamide structure](https://static.chemtradehub.com/structs/885/885275-44-5-aae0.webp)
![Methyl 4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylate structure Methyl 4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylate structure](https://static.chemtradehub.com/structs/943/943845-74-7-b7e5.webp)


