The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

文献情報

出版日 2018-04-30

DOI 10.1039/C8AN00295A

インパクトファクター 4.616

著者

Yuwei Tian, Brandon T. Ruotolo

原文を見る

要旨

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Mass spectrometry has evolved into a rapid and sensitive tool for assessing the structures, stabilities, and dynamics of such proteins. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics. We conclude by discussing the future of structural mass spectrometry, and its role in enabling the biopharmaceutical pipeline.

掲載誌

Analyst

CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

文献情報

おすすめジャーナル

関連文献

Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis

Syntheses of 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones through Au(i)-catalyzed Michael addition/6-endo-trig cyclization/aromatization cascade annulation

Palladium-catalyzed heck-type cascade cyclization of (Z)-1-iodo-1,6-dienes with N-tosyl hydrazones

Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

Catalytic enantioselective one-pot approach to cis- and trans-2,3-diaryl substituted 1,5-benzothiazepines

Rh-Catalyzed aminative dearomatization of 2-naphthols

Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

Front cover

こちらもおすすめ

3-イチチルビフェニルはどのように合成されますか？

8-溴-5-三氟甲基喹啉はどのように合成されますか？

ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか？

N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか？

イソステアロイルグリセリルは安全ですか？

1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか？

3-チオフェンスチオールの物理化学的性質は何ですか？

2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか？

CAS番号1316822-90-8の化合物は安全ですか？

Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか？

掲載誌

Analyst

おすすめ化合物

1-oxaspiro[4.4]nonan-6-one

8-Bromo-7-fluoro-2-methoxyquinoline

4-Chloro-2,3,5,6-tetrafluorophenol

N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-methionylglycine

(3alpha,5beta,6alpha,7alpha)-6-Ethylcholane-3,7,24-triol

おすすめサプライヤー