Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

文献情報

出版日 2018-06-12

DOI 10.1039/C8AN00225H

インパクトファクター 4.616

著者

Michal Bodík, Nikola Bugárová, Martina Labudová, Miriam Zaťovičová, Tibor Hianik, Mária Omastová, Matej Jergel, Silvia Pastoreková

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要旨

Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy. The nanometer-sized GO is known to permeate cell membranes. Herein we studied the cellular uptake pathways of GO nanoflakes by cancer and non-cancerous cell lines. By employing confocal Raman imaging, we were able to track the GO cellular uptake in living cells (C33 and MDCK) without any additional fluorescent or plasmonic labels. This specific progress in label-free Raman imaging of GO facilitates the monitoring of nanoflakes at the cellular level.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

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