Batch–flow hybrid synthesis of the antipsychotic clozapine

文献情報

出版日 2017-11-22

DOI 10.1039/C7RE00146K

インパクトファクター 4.239

著者

N. C. Neyt, D. L. Riley

原文を見る

要旨

The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies. We have reported the implementation of an on-the-fly purification by trituration which can also be utilised to perform solvent swaps. We have demonstrated this concept through the synthesis of the antipsychotic clozapine. In addition, we report a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

Batch–flow hybrid synthesis of the antipsychotic clozapine

文献情報

おすすめジャーナル

関連文献

Structure and local reactivity of PdAg/Pd(111) surface alloys

Back cover

New insight into the ZnO sulfidation reaction: mechanism and kinetics modeling of the ZnS outward growth

Organic ultra-thin film transistors with a liquid gate for extracellular stimulation and recording of electric activity of stem cell-derived neuronal networks

Naphthalene bisimides asymmetrically and symmetrically N-substituted with triarylamine – comparison of spectroscopic, electrochemical, electronic and self-assembly properties

Probing the balance of attraction and repulsion in binary mixtures of dimethyl sulfoxide and n-alcohols

Hydrogen oxidation at the Pt–BaZr0.1Ce0.7Y0.1Yb0.1O3−δ (BZCYYb) interface

Dynamics of local Stark effect observed for a complete D149 dye-sensitized solar cell

Polymer-regulated epitaxial crystallization of methanofullerene on mica

Formation of dimethylketene and methacrolein by reaction of the CH radical with acetone

こちらもおすすめ

間溴苯甲酰腈の市場動向や研究トレンドはどうですか？

去磺基萝卜硫苷とは何ですか？

Methyl 2-amino-5-(trifluoromethyl)benzoateに適用される法規ガイドラインは何ですか？

3-ブロモ-1,3,4,5-四水化-2H-1-ベンザアゼピン-2-オンは安全ですか？

三氟甲基ピリジン-2-甲アミン塩酸塩は安全ですか？

1-エチル-4-(4-硝基フェニル)ピペリジンは安全ですか？

1,1-ジメトキシプロパン-2-オンは安全ですか？

コバルト(II) 3,3'-{[(1S,2S)-1,2-ジメチルフENCYCLICALE-1,2-エチエンジイル]ビス[ニトロリルメチルイリデン]}ビス[4-オキソ-2-ペンテン-2-olate]について「に適用される法規ガイドラインは何ですか？

「カーバミル酸, N-[8-[[2-[[2-(2,6-ジオキソ-3-ピペリジニル)-2,3-ジオキソ-1,3-ジヒドロ-1H-イソイソインドール-4-イルオキシ]アセチル]アミノ]オクチル]-1,1-ジメチレチルエステル」はどのように保存すればよいですか？

FMoc-D-4-Aph(tBu-CbM)-OHはどのように保存すればよいですか？

掲載誌

Reaction Chemistry & Engineering

おすすめ化合物

O-Benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-threonine

2-Cyano-N-ethylacetamide

6-Bromo-1-methyl-1H-indazole

trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

おすすめサプライヤー